منابع مشابه
STIM2 drives Ca2+ oscillations through store-operated Ca2+ entry caused by mild store depletion.
Abstract Agonist-induced Ca(2+) oscillations in many cell types are triggered by Ca(2+) release from intracellular stores and driven by store-operated Ca(2+) entry. Stromal cell-interaction molecule (STIM) 1 and STIM2 serve as endoplasmic reticulum Ca(2+) sensors that, upon store depletion, activate Ca(2+) release-activated Ca(2+) channels (Orai1-3, CRACM1-3) in the plasma membrane. However, t...
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An important contribution to the study of store-operated Ca 2ϩ entry has come from investigations of inverte-respond to light with an increase in membrane conduc-tance, leading to a light-induced current (LIC) and mem-Calcium (Ca 2ϩ) is a crucial regulator of many physiologi-brane depolarization. The initial steps in this signaling cascade have been described. Absorption of photons cal processe...
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The mechanism of store-operated Ca2+ entry (SOCE) brings extracellular Ca2+ into cells after depletion of intracellular Ca2+ stores. Regulation of Ca2+ homeostasis by SOCE helps control various intracellular signaling functions in both non-excitable and excitable cells. Whereas essential components of the SOCE pathway are well characterized, molecular mechanisms underlying regulation of this pa...
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Ca(2+) release from intracellular stores and influx from extracellular reservoir regulate a wide range of physiological functions including muscle contraction and rhythmic heartbeat. One of the most ubiquitous pathways involved in controlled Ca(2+) influx into cells is store-operated Ca(2+) entry (SOCE), which is activated by the reduction of Ca(2+) concentration in the lumen of endoplasmic or ...
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Cytoplasmic Ca(2+) signals are central to numerous cell physiological processes, including cellular proliferation. Historically, much of the research effort in this area has focused on the role of Ca(2+) signals in cell-cycle progression. It is becoming clear, however, that the relationship between Ca(2+) signaling and the cell cycle is a 'two-way street'. Specifically, Ca(2+)-signaling pathway...
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ژورنال
عنوان ژورنال: Cell
سال: 1999
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)81977-7